SCHEMBL8956364

SCHEMBL8956364

O=C(Cc1ccc(F)cc1Oc1ccccc1)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CAMK2A Q9UQM7 1/20 0.54
TSPO P30536 3/20 0.46
HTR2A P28223 1/20 0.46
SLC6A4 P31645 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.43
CXCL8 P10145 1/20 0.42
LMNA P02545 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 1/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
AKR1C3 P42330 1/20 0.41
ERCC5 P28715 1/20 0.40
FEN1 P39748 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22186140 0.79 SLC6A4 (0.56) CAMK2ATSPOHTR2ASLC6A4
SCHEMBL966965 0.79 SIGMAR1 (0.46) HTR2ASMN1; SMN2MAPTMEN1NPC1
SCHEMBL3097072 0.76 MEN1 (0.47) L3MBTL1MAPTMEN1KMT2A
SCHEMBL1121618 0.76 RAB9A (0.46) SMN1; SMN2MAPTMEN1NPC1RAB9A
SCHEMBL6913020 0.75 SLC6A4 (0.49) CAMK2ATSPOHTR2ASLC6A4LMNA
SCHEMBL11510809 0.73 LTA4H (0.58) L3MBTL1LMNASMN1; SMN2MAPTNPC1
SCHEMBL11447649 0.72 CXCL8 (0.61) CAMK2AHTR2ASLC6A4CXCL8SMN1; SMN2
SCHEMBL30748257 0.72 CXCL8 (0.61) CAMK2AHTR2ASLC6A4CXCL8SMN1; SMN2
SCHEMBL10767038 0.72 SRD5A2 (0.60) L3MBTL1LMNAMAPTRAB9AERCC5
SCHEMBL8956299 0.72 SRD5A2 (0.60) L3MBTL1LMNAMAPTRAB9AERCC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5532374-A Method of preparation of bis-quinolines HITACHI CHEMICAL COMPANY, LTD. (JP) 1996-07-02 US disclosed