Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109932 | 0.93 | SIGMAR1 (0.47) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8110697 | 0.87 | SIGMAR1 (0.60) | SIGMAR1 | |
| SCHEMBL9449426 | 0.84 | SIGMAR1 (0.57) | SIGMAR1DRD2 | |
| SCHEMBL8117012 | 0.80 | SIGMAR1 (0.59) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7756732 | 0.80 | DRD2 (0.45) | SIGMAR1DRD2 | |
| SCHEMBL8116069 | 0.79 | CCR3 (0.57) | SIGMAR1 | |
| SCHEMBL7756751 | 0.79 | SIGMAR1 (0.44) | SIGMAR1DRD2 | |
| SCHEMBL7763028 | 0.77 | SIGMAR1 (0.37) | SIGMAR1DRD2 | |
| SCHEMBL8787068 | 0.76 | HTR1A (0.58) | DRD2 | |
| SCHEMBL8785431 | 0.76 | HTR1A (0.57) | SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |