Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.37 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400985 | 0.74 | ADRA2A (0.53) | ADRA2AALDH1A1ABL1GPR84 | |
| SCHEMBL8958469 | 0.74 | HCAR3 (0.39) | PLK1EPHX2 | |
| SCHEMBL3962294 | 0.73 | ABL1 (0.43) | ADRA2AALDH1A1ABL1PLK1 | |
| SCHEMBL28700733 | 0.72 | ABL1 (0.55) | ADRA2AALDH1A1ABL1GPR84 | |
| SCHEMBL8958338 | 0.71 | THRB (0.52) | ADRA2AALDH1A1ABL1GPR84PLK1 | |
| SCHEMBL8958462 | 0.71 | ADRA2A (0.46) | ADRA2AALDH1A1ABL1GPR84EPHX2 | |
| SCHEMBL7764821 | 0.70 | ALDH1A1 (0.71) | ADRA2AALDH1A1ABL1PLK1EPHX2 | |
| SCHEMBL10381587 | 0.70 | ADRA2A (0.50) | ADRA2AALDH1A1ABL1GPR84PLK1 | |
| SCHEMBL5605010 | 0.70 | ADRA2A (0.50) | ADRA2AALDH1A1ABL1GPR84PLK1 | |
| SCHEMBL9187399 | 0.70 | GPR84 (0.51) | ADRA2AABL1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | claimed |
| EP-0469887-B1 | Acetamide derivatives | ZENECA LTD (GB) | 1994-12-14 | — | — | EP | claimed |
| EP-0469888-B1 | Amidobenzenes | ICI PLC (GB) | 1994-09-28 | — | — | EP | claimed |
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5430060-A | Aldose reductase inhibitor | ZENECA LIMITED (GB) | 1995-07-04 | — | — | US | disclosed |
| EP-0469887-B1 | Acetamide derivatives | ZENECA LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| US-5270342-A | Acetamide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| US-5250570-A | Aldose reductase inhibitors for controlling side effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-05 | — | — | US | disclosed |
| EP-0408713-B1 | PHENYLSULPHONE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-05-19 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469887-A1 | Acetamide derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| EP-0408713-A1 | PHENYLSULPHONE DERIVATIVES. | ICI PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990008761-A1 | PHENYLSULPHONE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-09 | — | — | WO | disclosed |