Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870163 | 0.90 | SIGMAR1 (0.64) | SIGMAR1HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8871026 | 0.83 | SIGMAR1 (0.66) | SIGMAR1HTR1AGRIN2BCCR3 | |
| SCHEMBL10982732 | 0.83 | HTR1A (0.66) | HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5655532 | 0.79 | HTR1A (0.56) | HTR1ASLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL8109942 | 0.79 | GRIN1 (0.74) | HTR1ASLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL8870940 | 0.79 | SIGMAR1 (0.82) | SIGMAR1HTR1A | |
| SCHEMBL8870202 | 0.78 | SIGMAR1 (0.64) | SIGMAR1HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8948109 | 0.77 | HTR2A (0.61) | HTR1A | |
| SCHEMBL10392906 | 0.77 | HTR1A (0.62) | SIGMAR1HTR1ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8544949 | 0.73 | GRIN2B (0.55) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |