SCHEMBL8958875

SCHEMBL8958875

O=C(NCCOc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1Cl)C1CC1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
LMNA P02545 1/20 0.50
POLB P06746 1/20 0.50
KDR P35968 5/20 0.47
BRAF P15056 4/20 0.47
PPARA Q07869 4/20 0.43
PPARD Q03181 3/20 0.42
PPARG P37231 2/20 0.42
PTGDR2 Q9Y5Y4 2/20 0.42
MRGPRX4 Q96LA9 3/20 0.42
FFAR1 O14842 2/20 0.42
NPC1 O15118 1/20 0.41
PKM P14618 1/20 0.41
EPHX2 P34913 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8959189 0.87 PKM (0.56) MEN1KMT2ASMN1; SMN2PPARAPPARD
SCHEMBL8959049 0.85 PPARA (0.45) MEN1KMT2ASMN1; SMN2LMNAPPARA
SCHEMBL8958993 0.83 ABL1 (0.51) MEN1KMT2ASMN1; SMN2LMNAPOLB
SCHEMBL8959068 0.83 ABL1 (0.53) MEN1KMT2ASMN1; SMN2PPARAPPARD
SCHEMBL9158257 0.81 PPARA (0.47) PPARAPPARDPPARGMRGPRX4FFAR1
SCHEMBL8959167 0.81 KMT2A (0.50) MEN1KMT2ASMN1; SMN2POLBPPARA
SCHEMBL8959191 0.81 NPC1 (0.45) MEN1KMT2ASMN1; SMN2LMNAPOLB
SCHEMBL8959129 0.79 KMT2A (0.49) MEN1KMT2ASMN1; SMN2LMNAPPARA
SCHEMBL8959169 0.79 NPC1 (0.52) MEN1KMT2ASMN1; SMN2PTGDR2NPC1
SCHEMBL8959041 0.78 PKM (0.56) MEN1KMT2ASMN1; SMN2LMNAPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0514833-B1 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL CO (JP) 1996-01-17 EP claimed
US-5364966-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-15 US claimed
EP-0514833-A2 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-25 EP claimed
EP-0514833-B1 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL CO (JP) 1996-01-17 EP disclosed
US-5364966-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-15 US disclosed
US-5356930-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-10-18 US disclosed
EP-0514833-A2 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-25 EP disclosed