SCHEMBL8959068

SCHEMBL8959068

O=C(NCCOc1ccc(Oc2cccc(Cl)c2)cc1Cl)C1CC1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 2/20 0.53
PKM P14618 2/20 0.48
NPC1 O15118 1/20 0.48
EPHX2 P34913 1/20 0.48
RAB9A P51151 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
KMT2A Q03164 4/20 0.45
MEN1 O00255 3/20 0.44
MTNR1A P48039 3/20 0.43
MTNR1B P49286 2/20 0.43
ALDH1A1 P00352 1/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.41
PPARD Q03181 1/20 0.41
PPARA Q07869 1/20 0.41
OPRM1 P35372 1/20 0.41
OPRD1 P41143 1/20 0.41
MGLL Q99685 1/20 0.40
KLKB1 P03952 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8959189 0.91 PKM (0.56) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL8958993 0.89 ABL1 (0.51) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL8959167 0.89 KMT2A (0.50) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL8959122 0.88 ABL1 (0.43) ABL1PKMNPC1RAB9AKMT2A
SCHEMBL9163556 0.85 PPARD (0.47) PKMNPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL8959049 0.85 PPARA (0.45) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL9157470 0.83 PDE4A (0.41) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL9160000 0.83 MAPT (0.46) PKMNPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL8959169 0.83 NPC1 (0.52) ABL1PKMNPC1EPHX2RAB9A
SCHEMBL8958875 0.83 MEN1 (0.50) PKMNPC1EPHX2RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0514833-B1 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL CO (JP) 1996-01-17 EP claimed
US-5364966-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-15 US claimed
EP-0514833-A2 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-25 EP claimed
EP-0514833-B1 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL CO (JP) 1996-01-17 EP disclosed
US-5364966-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-15 US disclosed
US-5356930-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-10-18 US disclosed
EP-0514833-A2 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-25 EP disclosed