SCHEMBL8958987

SCHEMBL8958987

Cc1ccccc1Oc1ccc(OCCN)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.53
L3MBTL1 Q9Y468 5/20 0.45
MAPT P10636 4/20 0.45
RAB9A P51151 3/20 0.45
NPC1 O15118 2/20 0.45
HPGD P15428 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ATM Q13315 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
GLA P06280 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
CSNK2A1 P68400 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
HTR2A P28223 3/20 0.41
SLC6A4 P31645 3/20 0.41
KCNH2 Q12809 3/20 0.41
SLC6A2 P23975 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8959117 0.82 LTA4H (0.62) KDM4ESMN1; SMN2GLALTA4HPLA2G2A
SCHEMBL8958978 0.81 L3MBTL1 (0.49) ARL3MBTL1MAPTRAB9ANPC1
SCHEMBL8959114 0.79 HTR2A (0.47) ARSMN1; SMN2GLAHTR2ASLC6A4
SCHEMBL8959084 0.78 PPARA (0.56) SMN1; SMN2GLALTA4HPLA2G2APPARA
SCHEMBL8959091 0.78 LTA4H (0.46) MAPTHPGDKDM4ESMN1; SMN2GLA
SCHEMBL8958910 0.77 LTA4H (0.46) SMN1; SMN2GLACSNK2A1HTR2ASLC6A4
SCHEMBL3528979 0.77 KDM4E (0.68) L3MBTL1MAPTRAB9ANPC1HPGD
SCHEMBL8959054 0.75 LTA4H (0.44) MAPTHPGDKDM4ESMN1; SMN2GLA
SCHEMBL8959126 0.75 PPARA (0.48) SMN1; SMN2GLAHTR2ASLC6A4KCNH2
SCHEMBL8959169 0.75 NPC1 (0.52) ARRAB9ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0514833-B1 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL CO (JP) 1996-01-17 EP disclosed
US-5364966-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-15 US disclosed
US-5356930-A Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-10-18 US disclosed
EP-0514833-A2 Amide derivatives, their production processes and their compositions for the control of insect pests SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-11-25 EP disclosed