Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27528051 | 1.00 | HTR2A (0.45) | HTR2AHTR2CHTR7FABP4KDM4E | |
| SCHEMBL27342171 | 0.90 | HTR2C (0.45) | HTR2AHTR2CFABP4MCL1PRMT5 | |
| SCHEMBL8959547 | 0.90 | HTR2C (0.45) | HTR2AHTR2CFABP4MCL1PRMT5 | |
| SCHEMBL8959562 | 0.87 | HTR2C (0.46) | HTR2AHTR2CHTR7FABP4MTNR1A | |
| SCHEMBL27356666 | 0.87 | HTR2C (0.46) | HTR2AHTR2CHTR7FABP4MTNR1A | |
| SCHEMBL7997832 | 0.87 | KMO (0.48) | HTR2AHTR2CHTR7KDM4EALDH1A1 | |
| SCHEMBL8959608 | 0.83 | HTR2A (0.45) | HTR2AHTR2CMTNR1AMTNR1B | |
| SCHEMBL8001823 | 0.82 | MTNR1A (0.44) | HTR2AHTR2CKDM4EALDH1A1POLB | |
| SCHEMBL8959479 | 0.80 | HTR2C (0.46) | HTR2AHTR2CFABP4 | |
| SCHEMBL8959678 | 0.80 | HTR2C (0.46) | HTR2AHTR2CFABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |