Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | XPO1 | O14980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959761 | 0.79 | TRPM5 (0.39) | HTR2AHTR2C | |
| SCHEMBL8959614 | 0.78 | ICMT (0.39) | HTR2CICMTMMP1 | |
| Fumaric Acid SCHEMBL8959560 | 0.77 | TRPM5 (0.36) | HTR2AHTR2CICMTHTR2B | |
| Fumaric Acid SCHEMBL8959571 | 0.77 | TRPM5 (0.36) | HTR2AHTR2CICMTHTR2B | |
| SCHEMBL8959507 | 0.77 | HTR2C (0.60) | HTR2AHTR2CICMTTNFHTR2B | |
| SCHEMBL8959806 | 0.74 | HTR2A (0.40) | HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL8959880 | 0.71 | HTR2C (0.36) | HTR2AHTR2CICMTGNRHR | |
| Fumaric Acid SCHEMBL8959888 | 0.71 | HTR2C (0.36) | HTR2AHTR2CICMTGNRHR | |
| SCHEMBL8959947 | 0.69 | NOTUM (0.37) | HTR2AHTR2CHTR2B | |
| Fumaric Acid SCHEMBL8959900 | 0.67 | HTR2A (0.47) | HTR2AHTR2CICMTTNFHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |