Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.36 |
| ▸ | HTR2A known ✓ | P28223 | 6/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959888 | 1.00 | HTR2C (0.36) | HTR2CHTR2ANPSR1BLMICMT | |
| SCHEMBL9230492 | 0.90 | HTR2C (0.43) | HTR2CHTR2A | |
| Fumaric Acid SCHEMBL8959661 | 0.82 | HTR2C (0.45) | HTR2CHTR2ANPSR1LMNAPMP22 | |
| Fumaric Acid SCHEMBL8959671 | 0.82 | HTR2C (0.45) | HTR2CHTR2ANPSR1LMNAPMP22 | |
| SCHEMBL8959659 | 0.80 | ICMT (0.32) | ICMTKDM4E | |
| SCHEMBL8959654 | 0.80 | ICMT (0.32) | ICMTKDM4E | |
| Fumaric Acid SCHEMBL8959900 | 0.77 | HTR2A (0.47) | HTR2CHTR2ANPSR1BLMICMT | |
| Fumaric Acid SCHEMBL27340852 | 0.77 | HTR2A (0.47) | HTR2CHTR2ANPSR1BLMICMT | |
| Fumaric Acid SCHEMBL8959914 | 0.77 | HTR2A (0.47) | HTR2CHTR2ANPSR1BLMICMT | |
| Fumaric Acid SCHEMBL8959571 | 0.73 | TRPM5 (0.36) | HTR2CHTR2AICMTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |