Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.34 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA5A | P35218 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | ICMT | O60725 | 3/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959571 | 1.00 | TRPM5 (0.36) | TRPM5HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL8959806 | 0.89 | HTR2A (0.40) | TRPM5HTR2AHTR2CHTR2BP2RX7 | |
| Fumaric Acid SCHEMBL8959767 | 0.79 | TRPM5 (0.47) | TRPM5ALDH1A1 | |
| Fumaric Acid SCHEMBL8959756 | 0.79 | TRPM5 (0.47) | TRPM5ALDH1A1 | |
| Fumaric Acid SCHEMBL8959622 | 0.78 | HTR6 (0.48) | ALDH1A1CA2CA5ACA9ICMT | |
| Fumaric Acid SCHEMBL8959605 | 0.78 | HTR6 (0.48) | ALDH1A1CA2CA5ACA9ICMT | |
| SCHEMBL8959567 | 0.77 | HTR2A (0.36) | HTR2AHTR2CHTR2BICMT | |
| Fumaric Acid SCHEMBL8959509 | 0.73 | HTR2A (0.51) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959502 | 0.73 | HTR2A (0.51) | HTR2AHTR2CICMT | |
| Fumaric Acid SCHEMBL8959880 | 0.73 | HTR2C (0.36) | HTR2AHTR2CICMTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |