Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959654 | 1.00 | ICMT (0.32) | ICMTDAOKDM4EGRIN2BP2RX7 | |
| Fumaric Acid SCHEMBL8959880 | 0.80 | HTR2C (0.36) | ICMTKDM4E | |
| Fumaric Acid SCHEMBL8959888 | 0.80 | HTR2C (0.36) | ICMTKDM4E | |
| SCHEMBL9229358 | 0.78 | HTR2C (0.39) | DAOKDM4E | |
| SCHEMBL9229362 | 0.78 | HTR2C (0.39) | DAOKDM4E | |
| SCHEMBL8959664 | 0.70 | ICMT (0.40) | ICMTKDM4E | |
| SCHEMBL8959672 | 0.70 | ICMT (0.40) | ICMTKDM4E | |
| SCHEMBL8959883 | 0.69 | TRPM5 (0.31) | — | |
| SCHEMBL8959567 | 0.65 | HTR2A (0.36) | ICMT | |
| SCHEMBL9231573 | 0.64 | HTR2C (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |