Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.33 |
| ▸ | QPCT | Q16769 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9618165 | 0.78 | CHKA (0.42) | CHKAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8959775 | 0.77 | CHKA (0.58) | CHKAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1316266 | 0.71 | MEN1 (0.48) | CHKAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9673984 | 0.71 | CHRM2 (0.47) | CHKAHTTSMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL8959777 | 0.71 | GAA (0.40) | CHKAALDH1A1TSHRSMN1; SMN2TDP1 | |
| Bromide SCHEMBL8598361 | 0.70 | MEN1 (0.47) | CHKAHTTSMN1; SMN2 | |
| Iodide SCHEMBL5014654 | 0.70 | HTT (0.50) | CHKAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5444334 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL1973961 | 0.68 | MEN1 (0.48) | SMN1; SMN2 | |
| SCHEMBL1316129 | 0.68 | PABPC1 (0.43) | HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483480-B1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HUELS CHEMISCHE WERKE AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| US-5117027-A | Esterification | HULS AKTIENGESELLSCHAFT (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0483480-A1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HÜLS AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |