Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 7/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | HTR6 | P50406 | 3/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9725708 | 0.95 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL9725713 | 0.95 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9193895 | 0.88 | ADRA1A (0.76) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9200004 | 0.87 | ADRA1A (0.90) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9760100 | 0.86 | HTR1A (0.64) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9759666 | 0.85 | HTR1A (0.60) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9760272 | 0.84 | DRD2 (0.67) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9759409 | 0.84 | HTR1A (0.59) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9199195 | 0.83 | ADRA1D (0.81) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9193482 | 0.82 | ADRA1A (0.69) | ADRA1AADRA1DADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435749-B1 | Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use | SYNTHELABO (FR) | 1996-01-10 | — | — | EP | disclosed |
| EP-0435749-A1 | Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use | SYNTHELABO (FR) | 1991-07-03 | — | — | EP | disclosed |