Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.52 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.52 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9725713 | 1.00 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL8961083 | 0.95 | ADRA1A (0.69) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL5459952 | 0.83 | ADRA1D (0.91) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL5459957 | 0.83 | ADRA1D (0.91) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9193895 | 0.83 | ADRA1A (0.76) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9200004 | 0.82 | ADRA1A (0.90) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9760100 | 0.81 | HTR1A (0.64) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9759666 | 0.80 | HTR1A (0.60) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9760272 | 0.80 | DRD2 (0.67) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| Fumaric Acid SCHEMBL9741419 | 0.79 | ADRA1D (0.55) | ADRA1AADRA1DADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4139173-A | — | — | None | — | — | JP | disclosed |
| US-5164397-A | Hypotensive | SYNTHELABO (FR) | 1992-11-17 | — | — | US | disclosed |
| JP-H04139173-A | 2-AMINOPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE, ITS PRODUCTION AND MEDICAMENT CONTAINING THE SAME | SYNTHELABO SA | 1992-05-13 | — | — | JP | disclosed |