Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219620 | 0.84 | SMN1; SMN2 (0.67) | TP53SMN1; SMN2EPHX1EPHX2TSHR | |
| SCHEMBL2052253 | 0.82 | HTT (0.57) | TP53SMN1; SMN2KMT2AALDH1A1HTT | |
| SCHEMBL27874637 | 0.81 | LIPE (0.56) | SMN1; SMN2EPHX1KMT2AALDH1A1MEN1 | |
| SCHEMBL11440280 | 0.79 | DDX3X (0.63) | SMN1; SMN2KMT2AALDH1A1HTTLMNA | |
| SCHEMBL3765035 | 0.79 | NPC1 (0.46) | TP53SMN1; SMN2EPHX1EPHX2TSHR | |
| SCHEMBL10943929 | 0.78 | RAB9A (0.76) | TP53SMN1; SMN2EPHX1EPHX2KMT2A | |
| SCHEMBL10356812 | 0.78 | TP53 (0.48) | TP53SMN1; SMN2EPHX1EPHX2TSHR | |
| SCHEMBL9109432 | 0.77 | SMN1; SMN2 (0.60) | TP53SMN1; SMN2EPHX1EPHX2TSHR | |
| SCHEMBL11446077 | 0.76 | NPC1 (0.50) | KMT2AHTTMEN1MAPTNPC1 | |
| SCHEMBL5653581 | 0.76 | ALDH1A1 (0.61) | SMN1; SMN2TSHRKMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507616-B1 | Process for the preparation of trisubstituted ureas by reductive carbonylation | ARCO CHEM TECH (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5241118-A | Reacting nitroarene with carbon monoxide | ARCO CHEMICAL TECHNOLOGY, L.P. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0507616-A1 | Process for the preparation of trisubstituted ureas by reductive carbonylation | ARCO Chemical Technology, L.P. (US) | 1992-10-07 | — | — | EP | disclosed |