SCHEMBL8962388

SCHEMBL8962388

FC(F)(F)c1cccc(OC2(F)C(F)(F)C(F)(F)C2(F)Oc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
KDM4E B2RXH2 1/20 0.42
DRD2 P14416 1/20 0.41
KDM1A O60341 2/20 0.41
MAOB P27338 1/20 0.41
AOC3 Q16853 1/20 0.41
KIF11 P52732 1/20 0.40
PPARG P37231 3/20 0.40
PPARA Q07869 1/20 0.40
IDO1 P14902 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
LMNA P02545 1/20 0.39
PKM P14618 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8962385 0.84 TSHR (0.41) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL9798371 0.76 LTA4H (0.54) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL19890691 0.72 MGLL (0.48) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL4214531 0.72 TSHR (0.54) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL27579381 0.72 LTA4H (0.59) TSHRMAPK1L3MBTL1KIF11ALDH1A1
SCHEMBL167016 0.72 L3MBTL1 (0.58) TSHRMAPK1L3MBTL1KDM4EMAOB
SCHEMBL29782607 0.72 L3MBTL1 (0.58) TSHRMAPK1L3MBTL1KDM4EMAOB
SCHEMBL535445 0.72 TSHR (0.48) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL5608697 0.72 TSHR (0.48) TSHRMAPK1L3MBTL1SLC6A2SLC6A4
SCHEMBL11527555 0.72 KIF11 (0.51) TSHRMAPK1L3MBTL1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696309-A1 LUBRICANTS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1996-02-14 EP disclosed
US-5364547-A Lubricants containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
US-5364917-A Perfluorocyclobutane ring-containing polymers THE DOW CHEMICAL COMPANY (US) 1994-11-15 US disclosed
WO-1994025547-A1 LUBRICANTS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1994-11-10 WO disclosed
EP-0428708-B1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS DOW CHEMICAL CO (US) 1994-10-05 EP disclosed
EP-0428706-B1 PERFLUOROVINYL COMPOUNDS DOW CHEMICAL CO (US) 1994-07-13 EP disclosed
US-5162468-A Polymers containing perfluorocyclobutane rings THE DOW CHEMICAL COMPANY (US) 1992-11-10 US disclosed
US-5159038-A Flexibility, tensile strength DOW CHEMICAL COMPANY (US) 1992-10-27 US disclosed
US-5037917-A Polymerizing Monomers Containing At Least Two Perfluorovinyl Groups, Then Heating To Form Perfluorocyclobutane Rings THE DOW CHEMICAL COMPANY (US) 1991-08-06 US disclosed
US-5023380-A Monomer for thermoplastic resin THE DOW CHEMICAL COMPANY (US) 1991-06-11 US disclosed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
EP-0428706-A1 PERFLUOROVINYL COMPOUNDS. DOW CHEMICAL CO (US) 1991-05-29 EP disclosed
WO-1990015043-A2 PERFLUOROVINYL COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO disclosed