Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962857 | 0.96 | SPHK1 (0.40) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL8962887 | 0.93 | NISCH (0.33) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL8962929 | 0.87 | EP300 (0.34) | RAB9ANPC1GAANISCHS1PR1 | |
| SCHEMBL8962758 | 0.87 | NFKB1 (0.33) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL8962762 | 0.87 | NFKB1 (0.33) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL8963172 | 0.83 | SPHK1 (0.37) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL8963177 | 0.83 | SPHK1 (0.37) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL11203098 | 0.82 | HRH3 (0.43) | RARBRAB9ASMN1; SMN2SPHK1NPC1 | |
| SCHEMBL9300971 | 0.81 | MAP4K1 (0.32) | FFAR4 | |
| SCHEMBL11066526 | 0.81 | RAB9A (0.41) | RARBRAB9ASMN1; SMN2SPHK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |