Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16115650 | 0.86 | LMNA (0.32) | — | |
| SCHEMBL443270 | 0.80 | DNM1 (0.33) | DNM1ADRB2ADRB1ADRB3ATM | |
| SCHEMBL292814 | 0.78 | TSHR (0.36) | DNM1ADRB2ADRB1ADRB3ATM | |
| SCHEMBL828246 | 0.78 | ADH1B (0.35) | DNM1ADRB2ADRB1ADRB3ATM | |
| SCHEMBL115527 | 0.78 | LMNA (0.47) | DNM1ADRB2ADRB1ADRB3ATM | |
| SCHEMBL8974739 | 0.77 | DNM1 (0.31) | DNM1ADRB2ADRB1ADRB3 | |
| SCHEMBL10636666 | 0.77 | DNM1 (0.31) | DNM1ADRB2ADRB1ADRB3 | |
| SCHEMBL2021110 | 0.77 | — | — | |
| SCHEMBL30539136 | 0.76 | LMNA (0.45) | DNM1ADRB2ADRB1ADRB3ATM | |
| SCHEMBL6122979 | 0.74 | ADRB2 (0.39) | DNM1ADRB2ADRB1ADRB3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |
| WO-1992003131-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES | G.D. SEARLE & CO. (US) | 1992-03-05 | — | — | WO | claimed |
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0463995-B1 | Azo dyestuffs with 2-alkylamino-3-cyano-4,6-diaminopyridines as coupling components | CIBA GEIGY AG (CH) | 1996-02-21 | — | — | EP | disclosed |
| US-5462965-A | Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases | GD SEARLE & CO. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0543919-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES. | SEARLE & CO (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5196521-A | Colorfastness; red; polyesters | CIBA-GEIGY CORPORATION (US) | 1993-03-23 | — | — | US | disclosed |
| WO-1992003131-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES | G.D. SEARLE & CO. (US) | 1992-03-05 | — | — | WO | disclosed |
| EP-0463995-A1 | Azo dyestuffs with 2-alkylamino-3-cyano-4,6-diaminopyridines as coupling components | CIBA-GEIGY AG (CH) | 1992-01-02 | — | — | EP | disclosed |