SCHEMBL8964784

SCHEMBL8964784

Cc1ccc2nc(-c3cc4sc5ccccc5c4cc3O)sc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 11/20 0.46
RAB9A P51151 9/20 0.46
KDM4E B2RXH2 7/20 0.46
NPC1 O15118 7/20 0.46
APP P05067 6/20 0.46
SMN1; SMN2 Q16637 6/20 0.46
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
GAA P10253 3/20 0.46
SNCA P37840 2/20 0.46
POLB P06746 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
THRB P10828 1/20 0.46
ALOX15 P16050 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
HSD17B10 Q99714 1/20 0.46
NPSR1 Q6W5P4 2/20 0.46
GLA P06280 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8964898 0.77 RPS6KA3 (0.49) MAPTRAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL8964796 0.77 NPC1 (0.52) MAPTRAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL2790890 0.77 MAPT (0.69) MAPTRAB9AKDM4ENPC1APP
SCHEMBL8964541 0.76 NPC1 (0.41) MAPTRAB9AKDM4ENPC1APP
SCHEMBL27769428 0.76 MAPT (0.68) MAPTRAB9AKDM4ENPC1APP
SCHEMBL7197286 0.76 MAPT (0.72) MAPTRAB9AKDM4ENPC1APP
SCHEMBL8964798 0.75 ALDH1A1 (0.41) MAPTRAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL27969672 0.74 MAPT (0.70) MAPTRAB9AKDM4ENPC1APP
SCHEMBL19130391 0.73 GPR3 (0.56) MAPTRAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL5664358 0.73 MAPT (0.69) MAPTRAB9AKDM4ENPC1APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5587112-A DETECTION AND MEASUREMENT OF HIGH ENERGY PARTICLES AND ELECTROMAGNETC RADIATION PHILADELPHIA COLLEGE OF PHARMACY AND SCIENCE (US) 1996-12-24 US disclosed