Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964628 | 0.76 | CYP17A1 (0.42) | DBHESR1ESR2 | |
| SCHEMBL8965489 | 0.75 | ACHE (0.48) | — | |
| SCHEMBL8964385 | 0.74 | HSD17B10 (0.44) | DBHESR1ESR2 | |
| SCHEMBL27899502 | 0.74 | MAOA (0.43) | — | |
| SCHEMBL299357 | 0.74 | GAA (0.47) | MEP1BERN1 | |
| SCHEMBL14421368 | 0.74 | PTGS1 (0.45) | MEP1BDBHESR1ESR2 | |
| SCHEMBL36980 | 0.74 | MEP1B (0.44) | MEP1BDBHESR1ESR2ERN1 | |
| SCHEMBL2642238 | 0.72 | ACHE (0.50) | MEP1BDBHESR1ESR2ERN1 | |
| SCHEMBL6124950 | 0.70 | MEP1B (0.41) | MEP1BDBH | |
| SCHEMBL6302839 | 0.70 | MEP1B (0.41) | MEP1BDBH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410379-B1 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0410379-A2 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4981868-A | ENZYME INHIBITORS, HYPOTENSIVES | MERRELL DOW PHARMACEUTICAL (US) | 1991-01-01 | — | — | US | disclosed |