Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571852 | 0.81 | ESR1 (0.54) | ESR1ESR2LTA4H | |
| SCHEMBL8966077 | 0.77 | MEN1 (0.43) | ESR1ESR2 | |
| SCHEMBL9742252 | 0.75 | ESR1 (0.45) | ESR1ESR2 | |
| SCHEMBL8966115 | 0.74 | ESR1 (0.39) | ESR1ESR2 | |
| SCHEMBL9741860 | 0.73 | ESR1 (0.43) | ESR1ESR2 | |
| SCHEMBL8966114 | 0.73 | ESR1 (1.00) | ESR1ESR2 | |
| SCHEMBL13845292 | 0.73 | LTA4H (0.68) | ESR1ESR2ABCG2LTA4H | |
| SCHEMBL8966236 | 0.73 | ESR1 (0.53) | ESR1ESR2 | |
| SCHEMBL8966136 | 0.72 | ESR1 (0.56) | ESR1ESR2 | |
| SCHEMBL8965846 | 0.72 | ESR1 (0.38) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |