Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965946 | 0.81 | IDO1 (0.51) | FFAR1LMNAALDH1A1 | |
| SCHEMBL8965939 | 0.79 | MAOB (0.55) | HTT | |
| SCHEMBL8965693 | 0.78 | CYP3A4 (0.51) | — | |
| SCHEMBL8965867 | 0.78 | FFAR1 (0.38) | NUDT1NOS1NOS3FFAR1GAA | |
| SCHEMBL8965986 | 0.78 | NOS1 (0.52) | APPNOS1FFAR1NOS2ALDH1A1 | |
| SCHEMBL933699 | 0.77 | BCAT2 (0.55) | NUDT1GAALMNAHTTALDH1A1 | |
| SCHEMBL8966289 | 0.76 | THRA (0.44) | NOS1FFAR1SIRT2SIRT3SIRT1 | |
| SCHEMBL8965593 | 0.74 | NOS1 (0.45) | NOS1NOS3NOS2ALDH1A1BCAT2 | |
| SCHEMBL8965564 | 0.71 | TUBB1 (0.48) | ALDH1A1 | |
| SCHEMBL25060212 | 0.71 | APP (0.52) | APPSIRT2SIRT3SIRT1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |
| CN-1085901-A | Preparation contains the method for the antineoplastic pharmaceutical compositions of Imidazopyridazine derivative | WELLCOME FOUND (GB) | 1994-04-27 | — | — | CN | disclosed |
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| CN-1031532-A | HETEROCYCLIC COMPOUNDS | WELLCOME FOUND (GB) | 1989-03-08 | — | — | CN | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |