Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 10/20 | 0.52 |
| ▸ | NOS2 | P35228 | 5/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966289 | 0.86 | THRA (0.44) | NOS1NOS2FFAR1ALDH1A1BCAT2 | |
| SCHEMBL15618237 | 0.85 | NOS1 (0.44) | NOS1NOS2APPEGFRFYN | |
| SCHEMBL8965946 | 0.81 | IDO1 (0.51) | FFAR1ALDH1A1 | |
| SCHEMBL8965939 | 0.79 | MAOB (0.55) | — | |
| SCHEMBL8965693 | 0.78 | CYP3A4 (0.51) | — | |
| SCHEMBL8965857 | 0.78 | NUDT1 (0.43) | NOS1NOS2APPFFAR1ALDH1A1 | |
| SCHEMBL933699 | 0.77 | BCAT2 (0.55) | ALDH1A1BCAT2 | |
| SCHEMBL4383894 | 0.72 | IDO1 (0.58) | ALDH1A1TSHR | |
| SCHEMBL8965867 | 0.72 | FFAR1 (0.38) | NOS1FFAR1ALDH1A1BCAT2 | |
| SCHEMBL8965593 | 0.71 | NOS1 (0.45) | NOS1NOS2ALDH1A1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |