2-Pyrrolidone

2-Pyrrolidone

SCHEMBL12468588

C=C(C)C(=O)OC(C)O.O=C1CCCN1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.46
FKBP5 Q13451 1/20 0.40
CRBN Q96SW2 1/20 0.40
TSHR P16473 1/20 0.32
KDM4E B2RXH2 2/20 0.31
GAA P10253 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Caprolactam SCHEMBL6747085 0.94 FKBP5 (0.46) OR51E2FKBP5CRBNTSHRKDM4E
2-Pyrrolidone SCHEMBL28304484 0.87 OR51E2 (0.44) OR51E2FKBP5CRBNTSHRKDM4E
2-Pyrrolidone SCHEMBL28096599 0.84 OR51E2 (0.42) OR51E2FKBP5CRBN
2-Pyrrolidone SCHEMBL2030191 0.81 OR51E2 (0.39) OR51E2FKBP5CRBN
2-Pyrrolidone SCHEMBL27469716 0.81 OR51E2 (0.39) OR51E2FKBP5CRBNTSHR
SCHEMBL5604495 0.81 TSHR (0.35) TSHR
2-Pyrrolidone SCHEMBL7090022 0.81 ALDH1A1 (0.52) OR51E2FKBP5CRBNTSHRKDM4E
2-Pyrrolidone SCHEMBL8965954 0.78 OR51E2 (0.48) OR51E2FKBP5CRBNKDM4EGAA
Cyclohexane SCHEMBL4358222 0.78 TSHR (0.43) TSHR
2-Pyrrolidone SCHEMBL8133376 0.77 OR51E2 (0.47) OR51E2FKBP5CRBNTSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018106666-A1 ORAL CARE COPOLYMERS AND COMPOSITIONS AND METHODS FOR USE ISP INVESTMENTS LLC (US) 2018-06-14 WO claimed
EP-3377549-B1 PROLIFEROUS POLYMERS COMPRISING LACTAMIC MOIETIES ISP INVESTMENTS LLC (US) 2024-09-04 EP disclosed
US-10844154-B2 Proliferous copolymers comprising lactamic moieties ISP INVESTMENTS LLC (US) 2020-11-24 US disclosed
US-20180369120-A1 FRAGRANCE DELIVERY COMPOSITION COMPRISING COPOLYMERS OF ACRYLOYL LACTAM AND ALKYLMETHACRYLATES, PROCESS FOR PREPARING THE SAME, AND METHOD OF USE THEREOF ISP INVESTMENTS LLC (US) 2018-12-27 US disclosed
US-20180340034-A1 PROLIFEROUS COPOLYMERS COMPRISING LACTAMIC MOIETIES ISP INVESTMENTS LLC (US) 2018-11-29 US disclosed
US-10118981-B2 Lactamic polymer containing an acetoacetate moiety ISP INVESTMENTS LLC (US) 2018-11-06 US disclosed
EP-3377548-A1 FRAGRANCE DELIVERY COMPOSITION COMPRISING COPOLYMERS OF ACRYLOYL LACTAM AND ALKYLMETHACRYLATES, PROCESS FOR PREPARING THE SAME, AND METHOD OF USE THEREOF ISP Investments LLC (US) 2018-09-26 EP disclosed
EP-3377549-A1 PROLIFEROUS POLYMERS COMPRISING LACTAMIC MOIETIES ISP Investments LLC (US) 2018-09-26 EP disclosed
WO-2018106666-A1 ORAL CARE COPOLYMERS AND COMPOSITIONS AND METHODS FOR USE ISP INVESTMENTS LLC (US) 2018-06-14 WO disclosed
US-20170073447-A1 POLYMERS CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS LLC (US) 2017-03-16 US disclosed
US-20170022313-A1 LACTAMIC POLYMER CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS LLC (US) 2017-01-26 US disclosed
US-9505862-B2 Polymers containing an acetoacetate moiety ISP INVESTMENTS LLC (US) 2016-11-29 US disclosed
US-9464151-B2 Lactamic polymer containing an acetoacetate moiety ISP INVESTMENTS LLC (US) 2016-10-11 US disclosed
US-20150005465-A1 POLYMERS CONTAINING AN ACETOACETATE MOIETY AVOCA LLC 2015-01-01 US disclosed
US-20140296441-A1 LACTAMIC POLYMER CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS INC (US) 2014-10-02 US disclosed
US-20130261268-A1 LACTAMIC POLYMER CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS INC (US) 2013-10-03 US disclosed
EP-2627706-A2 LACTAMIC POLYMERS CONTAINING AN ACETOACETATE MOIETY Isp Investments Inc. (US) 2013-08-21 EP disclosed
WO-2013103528-A1 POLYMERS CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS INC. (US) 2013-07-11 WO disclosed
WO-2012148533-A1 LACTAMIC POLYMERS CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS INC. (US) 2012-11-01 WO disclosed
WO-2012051153-A2 LACTAMIC POLYMERS CONTAINING AN ACETOACETATE MOIETY ISP INVESTMENTS INC. (US) 2012-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180369120-A1 FRAGRANCE DELIVERY COMPOSITION COMPRISING COPOLYMERS OF ACRYLOYL LACTAM AND ALKYLMETHACRYLATES, PROCESS FOR PREPARING THE SAME, AND METHOD OF USE THEREOF ALK, APH1A, CUTA OR51E2 59/4885FKBP5 1930/4885CRBN 911/4885
US-10844154-B2 Proliferous copolymers comprising lactamic moieties PCNA, MKI67, CCNA1 OR51E2 4395/4885FKBP5 180/4885CRBN 302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.