Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8968082 | 1.00 | DRD3 (0.45) | DRD3SIGMAR1CNR1CNR2DRD2 | |
| SCHEMBL8967463 | 0.94 | SIGMAR1 (0.48) | DRD3SIGMAR1 | |
| Fumaric Acid SCHEMBL9227125 | 0.85 | DRD3 (0.45) | DRD3SIGMAR1CNR1CNR2DRD2 | |
| Fumaric Acid SCHEMBL9228751 | 0.85 | DRD3 (0.45) | DRD3SIGMAR1CNR1CNR2DRD2 | |
| Maleic Acid SCHEMBL9227118 | 0.85 | DRD3 (0.45) | DRD3SIGMAR1CNR1CNR2DRD2 | |
| Maleic Acid SCHEMBL9228744 | 0.85 | DRD3 (0.45) | DRD3SIGMAR1CNR1CNR2DRD2 | |
| SCHEMBL8967338 | 0.81 | DRD3 (0.59) | DRD3SIGMAR1DRD2DRD4 | |
| SCHEMBL8967226 | 0.81 | SIGMAR1 (0.66) | DRD3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9229456 | 0.81 | SIGMAR1 (0.52) | DRD3SIGMAR1DRD2 | |
| SCHEMBL8966528 | 0.81 | SIGMAR1 (0.50) | DRD3SIGMAR1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585116-B1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5389684-A | Treats disorder of central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1995-02-14 | — | — | US | disclosed |
| EP-0585116-A1 | 1-Alkoxy-naphthalene-2-carboxamide derivatives with high affinity for the serotonin 5-HT1A receptor | LILLY INDUSTRIES LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |