SCHEMBL8967652

SCHEMBL8967652

CN(CC12CCCN1CCC2)c1cccc(-c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.41
KDM4E B2RXH2 1/20 0.40
OPRM1 P35372 4/20 0.38
HTR7 P34969 8/20 0.38
KCNH2 Q12809 2/20 0.35
USP2 O75604 3/20 0.34
CYP1A2 P05177 3/20 0.34
CYP3A4 P08684 3/20 0.34
CYP2C9 P11712 3/20 0.34
ALDH1A1 P00352 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C19 P33261 2/20 0.34
HSD17B10 Q99714 2/20 0.34
TP53 P04637 1/20 0.34
MEN1 O00255 1/20 0.34
TSHR P16473 1/20 0.34
KMT2A Q03164 1/20 0.34
RECQL P46063 1/20 0.34
HSD11B1 P28845 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8967663 0.87 SIGMAR1 (0.47) SIGMAR1KDM4EOPRM1HTR7KCNH2
SCHEMBL8967658 0.81 SIGMAR1 (0.41) SIGMAR1KDM4EOPRM1KCNH2USP2
SCHEMBL8967609 0.73 SIGMAR1 (0.40) SIGMAR1KDM4EOPRM1HTR7KCNH2
SCHEMBL8967955 0.69 SIGMAR1 (0.47) SIGMAR1KDM4EOPRM1KCNH2
SCHEMBL8967712 0.68 MAPT (0.47) SIGMAR1KCNH2CYP1A2CYP3A4ALDH1A1
SCHEMBL8967651 0.67 SIGMAR1 (0.44) SIGMAR1OPRM1KCNH2CYP1A2TSHR
SCHEMBL8967681 0.66 SIGMAR1 (0.40) SIGMAR1ALDH1A1HSD17B10KMT2A
SCHEMBL21337170 0.65 SIGMAR1 (0.67) SIGMAR1OPRM1KCNH2TP53KMT2A
SCHEMBL1252082 0.65 ALDH1A1 (0.52) KDM4EALDH1A1HSD17B10TP53TSHR
SCHEMBL6723762 0.65 CHKA (0.50) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5530138-A A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1996-06-25 US claimed
EP-0647642-A1 1-Azabicyclo(3.3.0)octane derivatives and their use SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1995-04-12 EP claimed
US-5530138-A A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1996-06-25 US disclosed
EP-0647642-A1 1-Azabicyclo(3.3.0)octane derivatives and their use SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1995-04-12 EP disclosed