Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967652 | 0.87 | SIGMAR1 (0.41) | SIGMAR1OPRM1KDM4EKCNH2HTR7 | |
| SCHEMBL8967609 | 0.84 | SIGMAR1 (0.40) | SIGMAR1OPRM1KDM4EKCNH2SLC6A2 | |
| SCHEMBL8967541 | 0.79 | SIGMAR1 (0.37) | SIGMAR1OPRM1KDM4EKCNH2SLC6A2 | |
| SCHEMBL8967712 | 0.78 | MAPT (0.47) | SIGMAR1KCNH2MEN1KMT2ARAB9A | |
| SCHEMBL8967955 | 0.76 | SIGMAR1 (0.47) | SIGMAR1OPRM1KDM4EKCNH2SLC6A2 | |
| SCHEMBL8968120 | 0.76 | SLC6A3 (0.42) | SIGMAR1KDM4EKCNH2SLC6A2SLC6A4 | |
| SCHEMBL21337170 | 0.75 | SIGMAR1 (0.67) | SIGMAR1OPRM1KCNH2KMT2ARAB9A | |
| SCHEMBL8967651 | 0.74 | SIGMAR1 (0.44) | SIGMAR1OPRM1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL8968081 | 0.74 | CHEK1 (0.46) | SIGMAR1OPRM1KDM4EKCNH2KDM1A | |
| SCHEMBL8967681 | 0.73 | SIGMAR1 (0.40) | SIGMAR1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |