Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967663 | 0.84 | SIGMAR1 (0.47) | SIGMAR1TMEM97KDM4EOPRM1HTR7 | |
| SCHEMBL8968125 | 0.79 | MAPT (0.51) | SIGMAR1HTR7ALDH1A1MAPTRAB9A | |
| SCHEMBL8967761 | 0.78 | SIGMAR1 (0.40) | SIGMAR1KDM4EOPRM1KCNH2RAB9A | |
| SCHEMBL8967724 | 0.77 | SIGMAR1 (0.38) | SIGMAR1KDM4EKCNH2ALDH1A1SLC6A2 | |
| SCHEMBL8967665 | 0.76 | SMN1; SMN2 (0.39) | SIGMAR1OPRM1KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8967753 | 0.74 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8967652 | 0.73 | SIGMAR1 (0.41) | SIGMAR1KDM4EOPRM1HTR7KCNH2 | |
| SCHEMBL11044440 | 0.69 | CA12 (0.50) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL4928468 | 0.68 | SIGMAR1 (0.58) | SIGMAR1HTR7KDM1ASLC6A3 | |
| Hydrochloric Acid SCHEMBL10841191 | 0.68 | SIGMAR1 (0.44) | SIGMAR1KDM4EOPRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |