Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HCN1 | O60741 | 1/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967658 | 0.88 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2RAB9AKDM4E | |
| SCHEMBL8967761 | 0.85 | SIGMAR1 (0.40) | SIGMAR1OPRM1KCNH2RAB9AKDM4E | |
| SCHEMBL18458654 | 0.79 | OPRM1 (0.50) | SIGMAR1OPRM1KCNH2SLC6A3 | |
| SCHEMBL8968097 | 0.78 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2KDM4ESLC6A2 | |
| SCHEMBL8967505 | 0.77 | SIGMAR1 (0.35) | SIGMAR1OPRM1KCNH2CHRNA7SLC6A4 | |
| SCHEMBL8967663 | 0.76 | SIGMAR1 (0.47) | SIGMAR1OPRM1KCNH2RAB9AKDM4E | |
| SCHEMBL8968027 | 0.73 | TUBB3 (0.36) | SIGMAR1KDM4EHCN1HCN4 | |
| SCHEMBL21337552 | 0.72 | SIGMAR1 (0.45) | SIGMAR1OPRM1KCNH2KDM4EPRCP | |
| SCHEMBL8967652 | 0.69 | SIGMAR1 (0.41) | SIGMAR1OPRM1KCNH2KDM4E | |
| SCHEMBL8967593 | 0.68 | ALDH1A1 (0.33) | SIGMAR1OPRM1KCNH2KDM4ESLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |