Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968120 | 0.86 | SLC6A3 (0.42) | SIGMAR1SLC6A3SLC6A2HRH3KCNH2 | |
| SCHEMBL8967593 | 0.81 | ALDH1A1 (0.33) | SIGMAR1SLC6A3SLC6A2HRH3KCNH2 | |
| SCHEMBL8967665 | 0.78 | SMN1; SMN2 (0.39) | SIGMAR1SLC6A3SLC6A2KCNH2SLC6A4 | |
| SCHEMBL8967609 | 0.77 | SIGMAR1 (0.40) | SIGMAR1SLC6A3SLC6A2KCNH2SLC6A4 | |
| SCHEMBL8967753 | 0.76 | SIGMAR1 (0.41) | SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL8968097 | 0.75 | SIGMAR1 (0.35) | SIGMAR1SLC6A3SLC6A2KCNH2SLC6A4 | |
| SCHEMBL8968081 | 0.71 | CHEK1 (0.46) | SIGMAR1HRH3KCNH2KDM4E | |
| SCHEMBL8967649 | 0.70 | CA12 (0.49) | HRH3KCNH2KDM4EALDH1A1TSHR | |
| SCHEMBL9313557 | 0.70 | SIGMAR1 (0.52) | SIGMAR1CYP2D6ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5931116 | 0.69 | SIGMAR1 (0.50) | SIGMAR1CYP2D6ALDH1A1TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |