Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967681 | 0.88 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL8968125 | 0.78 | MAPT (0.51) | SIGMAR1ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL8968118 | 0.77 | RAB9A (0.35) | SIGMAR1ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL8967645 | 0.77 | RAB9A (0.35) | SIGMAR1ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL8967665 | 0.75 | SMN1; SMN2 (0.39) | SIGMAR1ALDH1A1SMN1; SMN2POLBAR | |
| SCHEMBL8967609 | 0.74 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL8554443 | 0.74 | CTSB (0.43) | SIGMAR1ALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL8967939 | 0.72 | KAT2B (0.50) | ALDH1A1LMNASMN1; SMN2GAARAB9A | |
| SCHEMBL754128 | 0.72 | ALDH1A1 (0.46) | SIGMAR1ALDH1A1POLBRAB9AMAPT | |
| Hydrochloric Acid SCHEMBL8968053 | 0.72 | KAT2B (0.51) | ALDH1A1LMNASMN1; SMN2GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |