Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553021 | 0.87 | LMNA (0.52) | MAPTLMNATHRBFKBP1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10842012 | 0.77 | ALDH1A1 (0.41) | ICMTMAPTLMNAALDH1A1RAB9A | |
| SCHEMBL3585157 | 0.76 | HRH3 (0.60) | MAPTLMNAFKBP1AALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8968053 | 0.75 | KAT2B (0.51) | MAPTLMNAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL8967682 | 0.75 | POLB (0.47) | ICMTLMNASMN1; SMN2MEN1HRH3 | |
| SCHEMBL3271959 | 0.74 | HRH3 (0.59) | MAPTLMNAFKBP1AALDH1A1SMN1; SMN2 | |
| SCHEMBL8968125 | 0.74 | MAPT (0.51) | MAPTLMNATHRBALDH1A1RAB9A | |
| SCHEMBL9003269 | 0.74 | MAPT (0.70) | MAPTALDH1A1GLASMN1; SMN2RAB9A | |
| SCHEMBL3995356 | 0.73 | HRH3 (0.57) | MAPTLMNAALDH1A1GLASMN1; SMN2 | |
| SCHEMBL8556050 | 0.73 | CTSB (0.43) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | claimed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | claimed |
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0647642-A1 | 1-Azabicyclo(3.3.0)octane derivatives and their use | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |