SCHEMBL896819

SCHEMBL896819

O=C(Nc1cnccc1Cl)Oc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
KDM4E B2RXH2 2/20 0.49
POLB P06746 2/20 0.46
ALDH1A1 P00352 3/20 0.45
CYP1A2 P05177 1/20 0.45
ROCK2 O75116 1/20 0.45
MAPT P10636 1/20 0.44
CYP19A1 P11511 1/20 0.44
MCL1 Q07820 1/20 0.43
RAD51 Q06609 1/20 0.43
GLA P06280 1/20 0.43
GAA P10253 1/20 0.43
HPGD P15428 1/20 0.43
ATM Q13315 1/20 0.43
TRPV1 Q8NER1 1/20 0.43
MAOB P27338 1/20 0.43
HTT P42858 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL896640 0.82 KMT2A (0.51) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL3984621 0.81 MEN1 (0.82) MEN1KMT2AKDM4EPOLBALDH1A1
SCHEMBL25234153 0.79 RAB9A (0.56) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL360914 0.79 KMT2A (0.51) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL896517 0.79 FAAH (0.43) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL4435014 0.79 POLB (0.62) MEN1KMT2APOLBALDH1A1ROCK2
SCHEMBL896721 0.79 GAA (0.49) MEN1KMT2AKDM4EALDH1A1CYP1A2
SCHEMBL7412368 0.77 ROCK2 (0.49) MEN1KMT2AKDM4EPOLBROCK2
SCHEMBL15890250 0.77 KMT2A (0.53) KMT2AKDM4EPOLBALDH1A1MAPT
SCHEMBL9915902 0.77 RORC (0.49) MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9688664-B2 Modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2017-06-27 US disclosed
US-9688664-B2 Modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2017-06-27 US disclosed
US-20150099761-A1 MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (US) 2015-04-09 US disclosed
US-20150099761-A1 MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (US) 2015-04-09 US disclosed
US-8940745-B2 Modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2015-01-27 US disclosed
US-8940745-B2 Modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2015-01-27 US disclosed
US-8901111-B2 Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2014-12-02 US disclosed
US-8901111-B2 Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2014-12-02 US disclosed
US-8901111-B2 Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase JANSSEN PHARMACEUTICA NV (BE) 2014-12-02 US disclosed
EP-2566861-B1 MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2014-05-14 EP disclosed
US-20120088741-A1 ARYL-SUBSTITUTED HETEROCYCLIC UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-12 US disclosed
US-20120088741-A1 ARYL-SUBSTITUTED HETEROCYCLIC UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-12 US disclosed
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-05 US disclosed
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-05 US disclosed
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2012-04-05 US disclosed
WO-2011139951-A1 MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2011-11-10 WO disclosed
WO-2010141817-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed
WO-2010141817-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed
WO-2010141809-A1 ARYL-SUBSTITUTED HETEROCYCLIC UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed
WO-2010141809-A1 ARYL-SUBSTITUTED HETEROCYCLIC UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150099761-A1 MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, APEH MEN1 4782/4885KMT2A 515/4885KDM4E 680/4885
US-20120083476-A1 HETEROARYL-SUBSTITUTED SPIROCYCLIC DIAMINE UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, DBH MEN1 3933/4885KMT2A 656/4885KDM4E 1200/4885
US-20120088741-A1 ARYL-SUBSTITUTED HETEROCYCLIC UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, APEH MEN1 4260/4885KMT2A 572/4885KDM4E 650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.