Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 9/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 4/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968832 | 0.87 | ABCC9 (0.42) | ABCC9KCNJ11KMT2AIMPDH2ADRB2 | |
| SCHEMBL8968199 | 0.78 | ABCC9 (0.45) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL8968203 | 0.78 | ABCC9 (0.45) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL8968218 | 0.75 | CYP11B1 (0.54) | MEN1KMT2ACYP11B2CYP11B1 | |
| SCHEMBL9463613 | 0.75 | ABCC9 (0.49) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL4685508 | 0.73 | HTR3E (0.47) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11156370 | 0.72 | ABCC9 (0.52) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11153500 | 0.72 | ABCC9 (0.52) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL8747731 | 0.72 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL3633060 | 0.72 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | claimed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | claimed |
| US-5547966-A | Aryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0656350-A1 | Biaryl urea and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |