Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312887 | 0.82 | PNMT (0.40) | ALDH1A1SMN1; SMN2SIRT6SIRT2MEN1 | |
| SCHEMBL654959 | 0.76 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2SIRT6SIRT2MEN1 | |
| SCHEMBL6591835 | 0.74 | PNMT (0.44) | ALDH1A1SIRT2MEN1KMT2APNMT | |
| SCHEMBL14721486 | 0.74 | BRD4 (0.59) | ALDH1A1SMN1; SMN2SIRT2AKR1B1 | |
| SCHEMBL29945643 | 0.72 | DPP7 (0.50) | ALDH1A1SIRT6SIRT2MEN1KMT2A | |
| SCHEMBL324724 | 0.68 | ADRA2A (0.51) | ALDH1A1SMN1; SMN2SIRT6MEN1KMT2A | |
| SCHEMBL29558059 | 0.68 | ADRA2A (0.51) | ALDH1A1SMN1; SMN2SIRT6MEN1KMT2A | |
| SCHEMBL1950525 | 0.67 | PNMT (0.54) | ALDH1A1SMN1; SMN2SIRT6SIRT2MEN1 | |
| SCHEMBL2103994 | 0.67 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2SIRT6MEN1KMT2A | |
| SCHEMBL1163008 | 0.67 | CASP1 (0.49) | ALDH1A1SMN1; SMN2SIRT6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504095-A | Aminobenzosultam derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0549666-B1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1994-11-23 | — | — | EP | disclosed |
| EP-0549666-A1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS. | PFIZER (US) | 1993-07-07 | — | — | EP | disclosed |
| WO-1992005164-A1 | NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1992-04-02 | — | — | WO | disclosed |