Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683172 | 0.83 | TAAR1 (0.42) | TAAR1LMNAL3MBTL1MAPT | |
| SCHEMBL682845 | 0.81 | CA1 (0.40) | SIGMAR1IDO1L3MBTL1NPC1RAB9A | |
| SCHEMBL8968693 | 0.81 | IDO1 (0.47) | TAAR1LMNAIDO1L3MBTL1MAOB | |
| SCHEMBL517859 | 0.76 | TAAR1 (0.50) | TAAR1HTR2AIDO1L3MBTL1KDM4E | |
| SCHEMBL682714 | 0.73 | KCNH2 (0.43) | TAAR1LMNAL3MBTL1KDM4EGAA | |
| SCHEMBL12776986 | 0.73 | KCNH2 (0.40) | MAPT | |
| SCHEMBL7008868 | 0.72 | SIGMAR1 (0.37) | TAAR1SIGMAR1IDO1L3MBTL1PYCR1 | |
| SCHEMBL2408318 | 0.72 | TAAR1 (0.42) | TAAR1HTR2ALMNASIGMAR1IDO1 | |
| SCHEMBL682092 | 0.71 | IDO1 (0.42) | LMNAIDO1L3MBTL1MEN1NPC1 | |
| SCHEMBL683151 | 0.71 | CALM1 (0.51) | TAAR1SIGMAR1L3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696284-A1 | HETEROCYCLIC DERIVATIVES | ZENECA LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |