Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.41 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8971128 | 1.00 | HPGD (0.50) | HPGDTSHRHCAR2TDP1AKR1B10 | |
| Methacrylic Acid SCHEMBL8917320 | 0.90 | TSHR (0.49) | HPGDTSHRTDP1AKR1B10AKR1B1 | |
| Styrene SCHEMBL5698366 | 0.84 | TSHR (0.59) | HPGDTSHRHCAR2TDP1THRB | |
| Styrene SCHEMBL5698364 | 0.84 | TSHR (0.59) | HPGDTSHRHCAR2TDP1THRB | |
| Juarezic Acid SCHEMBL8887961 | 0.83 | TSHR (0.55) | HPGDTSHRHCAR2TDP1AKR1B10 | |
| Juarezic Acid SCHEMBL1627203 | 0.83 | TSHR (0.55) | HPGDTSHRHCAR2TDP1AKR1B10 | |
| Butyl Fumarate SCHEMBL3956267 | 0.82 | HCAR2 (0.61) | HPGDTSHRHCAR2TDP1AKR1B10 | |
| Butyl Fumarate SCHEMBL3956264 | 0.82 | HCAR2 (0.61) | HPGDTSHRHCAR2TDP1AKR1B10 | |
| SCHEMBL15901443 | 0.82 | TSHR (0.51) | TSHRAKR1B10AKR1B1THRBAPP | |
| SCHEMBL30023403 | 0.81 | TSHR (0.63) | HPGDTSHRHCAR2TDP1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486451-A | FORMING A DISPERSION OF SILVER HALIDE GRAINS IN THE PRESENCE OF A HYDROPHILIC COLLOID AND REMOVING BY-PRODUCTS BY LOWERING THE PH TO BRING ABOUT COAGULATION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| US-5484693-A | ELECTROCONDUCTIVE CROSSLINKED POLYMERS WITH STYRENESULFONIC ACID AND MALEIC ACID WITH EPOXIDE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0645672-A1 | Method for preparing silver halide photographic emulsions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-03-29 | — | — | EP | disclosed |