Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3953294 | 0.85 | MTNR1A (0.59) | MTNR1AMTNR1BMAOAAOC3 | |
| Hydrochloric Acid SCHEMBL11128673 | 0.83 | MTNR1A (0.57) | MTNR1AMTNR1BMAOAAOC3 | |
| SCHEMBL11013203 | 0.80 | RXRA (0.51) | MTNR1AMTNR1BRXRARXRBMAOA | |
| SCHEMBL11405631 | 0.79 | OGG1 (0.57) | MTNR1AMTNR1BAOC3 | |
| SCHEMBL8469211 | 0.76 | RXRA (0.72) | RXRARXRBMAOAMAOBGABRA1 | |
| SCHEMBL25822208 | 0.74 | MTNR1A (0.44) | MTNR1AMTNR1BMAOA | |
| SCHEMBL25818072 | 0.74 | MTNR1A (0.44) | MTNR1AMTNR1BMAOA | |
| SCHEMBL30201393 | 0.74 | MTNR1A (0.48) | MTNR1AMTNR1BRXRARXRBFFAR4 | |
| SCHEMBL10552651 | 0.72 | RXRA (0.46) | RXRARXRBMAOAMAOBGABRA1 | |
| SCHEMBL18903911 | 0.72 | MAPT (0.47) | RXRARXRBMAOAMAOBGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545425-B1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5268468-A | Or optical isomers thereof | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-07 | — | — | US | disclosed |
| US-5229417-A | Obsessive compulsive disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0545425-A1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-09 | — | — | EP | disclosed |