Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11128673 | 0.98 | MTNR1A (0.57) | MTNR1AMTNR1BAOC3MAOAPTGS1 | |
| SCHEMBL8972003 | 0.85 | MTNR1A (0.49) | MTNR1AMTNR1BAOC3MAOA | |
| SCHEMBL13452617 | 0.82 | MTNR1A (0.61) | MTNR1AMTNR1BMAOAPTGS1SLC6A4 | |
| SCHEMBL9320746 | 0.80 | MTNR1A (0.64) | MTNR1AMTNR1BSLC6A4ADRB2ADRB1 | |
| SCHEMBL11405631 | 0.79 | OGG1 (0.57) | MTNR1AMTNR1BAOC3SLC6A4 | |
| Methyl Alcohol SCHEMBL11162488 | 0.78 | MTNR1A (0.62) | MTNR1AMTNR1BSLC6A4ADRB2ADRB1 | |
| SCHEMBL3160069 | 0.77 | MTNR1A (0.50) | MTNR1AMTNR1BMAOAPTGS1SLC6A4 | |
| SCHEMBL5729049 | 0.77 | MTNR1A (0.50) | MTNR1AMTNR1BMAOAPTGS1SLC6A4 | |
| SCHEMBL3469518 | 0.77 | MTNR1A (0.50) | MTNR1AMTNR1BMAOAPTGS1SLC6A4 | |
| SCHEMBL9870637 | 0.76 | MTNR1A (0.53) | MTNR1AMTNR1BMAOAPTGS1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713486-A4 | COMBINATION THERAPY FOR DEMENTIA,DEPRESSION AND APATHY | SHELDON LESLIE JAMES (CA) | 2009-04-29 | — | — | EP | disclosed |
| EP-1713486-A1 | COMBINATION THERAPY FOR DEMENTIA,DEPRESSION AND APATHY | Sheldon, Leslie James (CA) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005053703-A1 | COMBINATION THERAPY FOR DEMENTIA, DEPRESSION AND APATHY | SHELDON LESLIE JAMES (CA) | 2005-06-16 | — | — | WO | disclosed |