SCHEMBL8974158

SCHEMBL8974158

CC(=O)c1ccc2cccc(C)c2c1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
KMT2A Q03164 3/20 0.47
KDM4E B2RXH2 3/20 0.47
HSD17B10 Q99714 3/20 0.47
MEN1 O00255 2/20 0.47
TSHR P16473 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
BRPF1 P55201 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
HPGD P15428 3/20 0.43
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
CYP2C9 P11712 2/20 0.38
MAPT P10636 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP3A4 P08684 2/20 0.38
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2788366 0.86 ALDH1A1 (0.65) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL12800164 0.84 MAPT (0.49) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL23259556 0.81 BRPF1 (0.44) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL27728332 0.79 GABRA1 (0.47) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL27728335 0.78 GABRA1 (0.46) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL2051695 0.77 ALDH1A1 (0.69) ALDH1A1KMT2AKDM4EHSD17B10BRPF1
SCHEMBL29743740 0.77 ALDH1A1 (0.69) ALDH1A1KMT2AKDM4EHSD17B10BRPF1
SCHEMBL27074596 0.77 ALDH1A1 (0.56) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL27728331 0.76 GPR35 (0.49) ALDH1A1KMT2AKDM4EHSD17B10MEN1
SCHEMBL2981975 0.75 CDK2 (0.57) ALDH1A1KMT2AKDM4EHSD17B10MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101412775-B Catalyst precursor for polymerization of propylene or combined polymerization, and preparation thereof BEIJING JINDINGKE CHEMICAL TECHNOLOGY CO LTD 2010-12-22 CN disclosed
CN-101139407-B Catalyst precursor for ethylene polymerization or copolymerization and preparation method thereof BEIJING JINDINGKE CHEMICAL TECHNOLOGY CO LTD 2010-10-06 CN disclosed
CN-101412775-A Catalyst activity component for polymerization of propylene or combined polymerization, catalyst precursor containing the same and preparation thereof BEIJING JINDINGKE CHEMICAL TEC (CN) 2009-04-22 CN disclosed
CN-101139407-A Catalyst active component for ethylene polymerization or copolymerization and catalyst precursor comprising the active component and preparation method thereof BEIJING JINDINGKE CHEMICAL TEC (CN) 2008-03-12 CN disclosed
US-5527948-A SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS EISAI CORP. LTD. (JP) 1996-06-18 US disclosed
US-5298649-A Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases EISAI CO., LTD. (JP) 1994-03-29 US disclosed
EP-0376288-B1 Naphthalene derivative EISAI CO LTD (JP) 1994-03-09 EP disclosed
US-5134111-A Inhibitors of interleukin-1 as antiinflammatory agents EISAI CO., LTD. (JP) 1992-07-28 US disclosed