Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.51 |
| ▸ | CA1 | P00915 | 7/20 | 0.50 |
| ▸ | CA2 | P00918 | 7/20 | 0.50 |
| ▸ | CA9 | Q16790 | 7/20 | 0.50 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974198 | 0.89 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8974407 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8974757 | 0.87 | CA2 (0.41) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8974660 | 0.86 | CA1 (0.51) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8973781 | 0.85 | KIF11 (0.59) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8974120 | 0.84 | CA2 (0.49) | CA1CA2CA9CA12CA14 | |
| SCHEMBL8974835 | 0.84 | CA1 (0.44) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8974231 | 0.82 | CA9 (0.46) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8973691 | 0.81 | CA1 (0.43) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL214628 | 0.80 | PTGS2 (0.56) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |