Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975642 | 0.77 | MAPT (0.40) | TSHRRAB9AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL124863 | 0.72 | NPSR1 (0.55) | TSHRRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL8975377 | 0.72 | MTNR1A (0.42) | TSHRRAB9AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL9421959 | 0.71 | LTA4H (0.50) | TSHRTDP1HPGDHSD17B10CA4 | |
| SCHEMBL3198121 | 0.71 | TSHR (0.52) | TSHRRAB9AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL15234422 | 0.71 | ELANE (0.40) | TSHRMAPTTDP1HPGDHSD17B10 | |
| SCHEMBL28738466 | 0.70 | CES1 (0.45) | TSHRMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL7085752 | 0.70 | CA4 (0.48) | TSHRRAB9AMAPTTDP1CA4 | |
| SCHEMBL8646869 | 0.69 | ALDH1A1 (0.52) | TSHRMAPTTDP1SMN1; SMN2HPGD | |
| SCHEMBL14336915 | 0.68 | KMT2A (0.54) | TSHRRAB9AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |