Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738466 | 0.81 | CES1 (0.45) | MAPTL3MBTL1TSHRCES2CES1 | |
| SCHEMBL8975628 | 0.77 | TSHR (0.45) | MAPTSMN1; SMN2L3MBTL1LMNARAB9A | |
| SCHEMBL2123773 | 0.72 | NPSR1 (0.55) | MAPTSMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL10534542 | 0.71 | CHRNB2 (0.39) | L3MBTL1TSHRALDH1A1 | |
| SCHEMBL9421959 | 0.71 | LTA4H (0.50) | RECQLL3MBTL1ALOX15LMNATSHR | |
| SCHEMBL15234422 | 0.71 | ELANE (0.40) | MAPTL3MBTL1ALOX15LMNAELANE | |
| SCHEMBL8467278 | 0.69 | ELANE (0.70) | MAPTSMN1; SMN2RECQLL3MBTL1LMNA | |
| SCHEMBL6572639 | 0.69 | LTA4H (0.42) | MAPTL3MBTL1LMNATSHRTDP1 | |
| Diphenylether SCHEMBL8533552 | 0.69 | LTA4H (0.57) | SMN1; SMN2ALOX15RAB9ATSHRNPC1 | |
| SCHEMBL8029428 | 0.68 | LTA4H (0.38) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |