SCHEMBL8979286

SCHEMBL8979286

Nc1ncnc2c1[nH]c(=O)n2[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.53
▸ TYMS P04818 2/20 0.52
▸ ENPP1 P22413 2/20 0.50
▸ P2RY1 P47900 1/20 0.50
▸ DTYMK P23919 2/20 0.49
▸ TRPM2 O94759 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16871807 1.00 POLB (0.53) POLBTYMSENPP1P2RY1DTYMK
SCHEMBL29941654 0.93 POLB (0.54) POLBTYMSENPP1P2RY1DTYMK
SCHEMBL23679561 0.93 POLB (0.49) POLBTYMSENPP1P2RY1DTYMK
SCHEMBL23679569 0.93 POLB (0.49) POLBTYMSENPP1P2RY1DTYMK
SCHEMBL15794517 0.92 DTYMK (0.55) POLBENPP1P2RY1DTYMKTRPM2
Phosphoric Acid SCHEMBL16871802 0.87 ADORA3 (0.50) POLBENPP1P2RY1DTYMKTRPM2
SCHEMBL31685561 0.86 TYMS (0.51) TYMS
SCHEMBL5982753 0.85 ADORA3 (0.53) —
SCHEMBL5982748 0.85 ADORA3 (0.53) —
SCHEMBL439797 0.85 ADORA3 (0.53) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE TEAM MEDICAL, LLC 2025-09-18 — — US disclosed
EP-3130597-B1 OLIGONUCLEOTIDE HAVING A NON-NATURAL NUCLEOTIDE AT THE 5'-TERMINAL KYOWA KIRIN CO LTD (JP) 2021-11-10 — — EP disclosed
EP-2891717-B1 OLIGONUCLEOTIDE KYOWA KIRIN CO LTD (JP) 2020-04-29 — — EP disclosed
US-10378011-B2 Oligonucleotide KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-08-13 — — US disclosed
US-10378011-B2 Oligonucleotide KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-08-13 — — US disclosed
US-10342819-B2 Oligonucleotide having non-natural nucleotide at 5′-terminal thereof KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-07-09 — — US disclosed
US-10342819-B2 Oligonucleotide having non-natural nucleotide at 5′-terminal thereof KYOWA HAKKO KIRIN CO., LTD. (JP) 2019-07-09 — — US disclosed
US-20170354673-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF KYOWA HAKKO KIRIN CO., LTD. (JP) 2017-12-14 — — US disclosed
US-20170354673-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF KYOWA HAKKO KIRIN CO., LTD. (JP) 2017-12-14 — — US disclosed
EP-3130597-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF Kyowa Hakko Kirin Co., Ltd. (JP) 2017-02-15 — — EP disclosed
US-20150376611-A1 OLIGONUCLEOTIDE KYOWA KIRIN CO., LTD. (JP) 2015-12-31 — — US disclosed
US-20150376611-A1 OLIGONUCLEOTIDE KYOWA KIRIN CO., LTD. (JP) 2015-12-31 — — US disclosed
EP-2891717-A1 OLIGONUCLEOTIDE Kyowa Hakko Kirin Co., Ltd. (JP) 2015-07-08 — — EP disclosed
US-5512486-A Single step signal group-imidazole labeling of organic phosphate groups under aqueous conditions NORTHEASTERN UNIVERSITY (US) 1996-04-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10378011-B2 Oligonucleotide HNRNPA3, AGO2, RBM3 POLB 785/4885TYMS 1779/4885ENPP1 1738/4885
US-10342819-B2 Oligonucleotide having non-natural nucleotide at 5′-terminal thereof RNGTT, UPF1, NSUN3 POLB 59/4885TYMS 139/4885ENPP1 1187/4885
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE SYNCRIP, SNRPA, RNASE1 POLB 712/4885TYMS 3277/4885ENPP1 309/4885
US-20170354673-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF RNGTT, UPF1, NSUN3 POLB 60/4885TYMS 141/4885ENPP1 1203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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