Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 7/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 5/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10493681 | 0.87 | ATM (0.58) | ATMNPC1RAB9AALDH1A1POLB | |
| SCHEMBL2627997 | 0.75 | ACHE (0.47) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL28698615 | 0.75 | RAB9A (0.33) | ATMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4144064 | 0.74 | ALDH1A1 (0.44) | ATMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16469707 | 0.73 | NPC1 (0.43) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL28438628 | 0.73 | RAB9A (0.45) | ATMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15066601 | 0.73 | ATM (0.44) | ATMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28912018 | 0.73 | CHRNB2 (0.36) | ATMNPC1RAB9ABCL2KDM4E | |
| SCHEMBL3443794 | 0.72 | KDM4E (0.43) | ATMNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16243905 | 0.72 | ATM (0.42) | ATMNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |