Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947117 | 0.84 | TSHR (0.41) | TSHRPKMPRMT5WDR77MAOB | |
| SCHEMBL8639215 | 0.84 | TSHR (0.41) | TSHRPKMPRMT5WDR77MAOB | |
| SCHEMBL13438368 | 0.81 | TSHR (0.39) | TSHRPKMPRMT5WDR77MAOB | |
| SCHEMBL8578943 | 0.81 | PRMT5 (0.39) | TSHRPKMPRMT5WDR77KDM4E | |
| SCHEMBL13063351 | 0.80 | PKM (0.38) | TSHRPKMPRMT5WDR77 | |
| SCHEMBL7386417 | 0.80 | ALDH1A1 (0.46) | TSHRKDM4EKMT2ASMN1; SMN2MAPT | |
| SCHEMBL9173037 | 0.79 | HTR7 (0.37) | TSHRPKM | |
| SCHEMBL8980569 | 0.79 | TDP1 (0.41) | TSHRPKMPRMT5WDR77KDM4E | |
| SCHEMBL9809901 | 0.78 | ACHE (0.46) | MAOBKDM4EHTTKMT2ASMN1; SMN2 | |
| SCHEMBL8980560 | 0.78 | PKM (0.36) | TSHRPKMPRMT5WDR77MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |