SCHEMBL8982

SCHEMBL8982

Cc1nc2cc(Br)ccc2[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMS P04818 1/20 0.49
ALDH1A1 P00352 2/20 0.47
EGFR P00533 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
MAPT P10636 3/20 0.43
POLB P06746 2/20 0.43
HPGD P15428 2/20 0.43
KDM4E B2RXH2 2/20 0.43
RAB9A P51151 2/20 0.42
MAPK1 P28482 1/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
KMT2A Q03164 1/20 0.42
HSP90AA1 P07900 1/20 0.42
ESR2 Q92731 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
HAVCR2 Q8TDQ0 1/20 0.42
NOS1 P29475 1/20 0.41
METAP2 P50579 1/20 0.41
CSNK2A1 P68400 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31473884 0.84 ALDH1A1 (0.61) TYMSALDH1A1EGFRSMN1; SMN2MAPT
SCHEMBL8981 0.84 ALDH1A1 (0.61) TYMSALDH1A1EGFRSMN1; SMN2MAPT
SCHEMBL12540 0.79 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2MAPTPOLBHPGD
SCHEMBL4483413 0.79 NOS1 (0.44) ALDH1A1RAB9AMAPK1NOS1METAP2
SCHEMBL1170673 0.79 PDPK1 (0.51) ALDH1A1SMN1; SMN2KDM4ERAB9ANPC1
SCHEMBL25457211 0.79 RAB9A (0.53) ALDH1A1SMN1; SMN2MAPTPOLBHPGD
SCHEMBL14474327 0.78 CASP3 (0.45) TYMSALDH1A1EGFRMAPTHPGD
SCHEMBL11816656 0.78 EGFR (0.44) ALDH1A1EGFRSMN1; SMN2POLBHPGD
SCHEMBL12052868 0.78 POLB (0.51) ALDH1A1SMN1; SMN2MAPTPOLBHPGD
SCHEMBL1405835 0.76 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2MAPTPOLBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119425419-A Metal-organic framework composite membrane for helium and methane mixed gas separation and preparation method and application thereof 苏州大学 2025-02-14 CN claimed
EP-1976829-A2 N-(6-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. (US) 2008-10-08 EP claimed
US-20070265262-A1 N-(6-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. 2007-11-15 US claimed
WO-2007070556-A2 N-(6-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. (US) 2007-06-21 WO claimed
US-20260125378-A2 Heterocyclic Compounds BEONE MEDICINES I GMBH (CH) 2026-05-07 US disclosed
EP-4702021-A1 COMPOUNDS CAPABLE OF MODULATING GPR65 Pathios Therapeutics Limited (GB) 2026-03-04 EP disclosed
EP-4288426-B1 QUINOXALINE DERIVATIVES AND USES THEREOF BLACK DIAMOND THERAPEUTICS INC (US) 2026-02-04 EP disclosed
EP-4658650-A1 HETEROCYCLIC COMPOUNDS Beone Medicines I GmbH (CH) 2025-12-10 EP disclosed
WO-2025245484-A1 FOXN1 ACTIVATORS THYMOFOX INC. (US) 2025-11-27 WO disclosed
US-20250353846-A1 Heterocyclic Compounds BEONE MEDICINES I GMBH (CH) 2025-11-20 US disclosed
CN-120424484-A Scratch-resistant high-transparency polycarbonate with self-repairing function and preparation method thereof 青岛国恩科技股份有限公司 2025-08-05 CN disclosed
CN-119425419-A Metal-organic framework composite membrane for helium and methane mixed gas separation and preparation method and application thereof 苏州大学 2025-02-14 CN disclosed
US-20070043068-A1 to treat diseases mediated by kinase activity; for example: [3-(2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-methyl-phenyl-amine SGX PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed
US-20070043068-A1 to treat diseases mediated by kinase activity; for example: [3-(2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-methyl-phenyl-amine SGX PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed
EP-1685124-A1 SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN MERCK SHARP & DOHME LTD. (GB) 2006-08-02 EP disclosed
WO-2006015123-A1 PYRROLO-PYRIDINE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2006-02-09 WO disclosed
US-20060030583-A1 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2006-02-09 US disclosed
WO-2005047279-A1 SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN MERCK SHARP & DOHME LIMITED (GB) 2005-05-26 WO disclosed
EP-1509497-A1 CALCIUM RECEPTOR MODULATING ARYLALKYLAMINES Amgen Inc. (US) 2005-03-02 EP disclosed
WO-2003099776-A1 CALCIUM RECEPTOR MODULATING ARYLALKYLAMINES AMGEN INC. (US) 2003-12-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125378-A2 Heterocyclic Compounds NFATC1, CD4, MALT1 TYMS 398/4885ALDH1A1 2837/4885EGFR 875/4885
US-20070265262-A1 N-(6-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS ZC3HAV1, HAVCR2, ZC3HAV1L TYMS 761/4885ALDH1A1 4167/4885EGFR 3991/4885
US-20250353846-A1 Heterocyclic Compounds NFATC1, CD4, ACIN1 TYMS 255/4885ALDH1A1 1006/4885EGFR 1358/4885
US-20060030583-A1 Pyrrolo-pyridine kinase modulators MAP3K20, MAP4K2, MAP3K19 TYMS 731/4885ALDH1A1 4474/4885EGFR 877/4885
US-20070043068-A1 to treat diseases mediated by kinase activity; for example: [3-(2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-methyl-phenyl-amine MAP3K20, MAP4K2, MAP3K6 TYMS 1488/4885ALDH1A1 4281/4885EGFR 566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.