Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 5/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4230108 | 0.99 | SIGMAR1 (0.58) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| SCHEMBL10035588 | 0.97 | HTR7 (0.57) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| Hydrochloric Acid SCHEMBL2136320 | 0.96 | HTR7 (0.56) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| SCHEMBL8982250 | 0.90 | DRD4 (0.58) | HTR7ABCB1DRD3 | |
| SCHEMBL8981452 | 0.90 | HTR7 (0.58) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| SCHEMBL8983429 | 0.90 | HTR7 (0.72) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| SCHEMBL5410336 | 0.89 | HTR7 (0.57) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| Hydrochloric Acid SCHEMBL4216217 | 0.89 | HTR7 (0.57) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| SCHEMBL8983653 | 0.89 | L3MBTL1 (0.61) | SIGMAR1TMEM97HTR7ABCB1DRD2 | |
| Hydrochloric Acid SCHEMBL4228196 | 0.89 | DRD4 (0.57) | HTR7ABCB1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | SIGMAR1 140/4885TMEM97 100/4885HTR7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.