Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | STK3 | Q13188 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985407 | 0.84 | MAPK14 (0.51) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| SCHEMBL8985449 | 0.83 | OPRD1 (0.38) | AURKAROCK2CHEK2PIM1CDK2 | |
| SCHEMBL8985262 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| SCHEMBL8985461 | 0.81 | PTGS2 (0.68) | AURKAROCK2CHEK2PIM1CDK2 | |
| SCHEMBL8985195 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1KDM4EMT-CO1MT-CO2 | |
| SCHEMBL8985469 | 0.79 | AURKA (0.47) | AURKAROCK2CHEK2PIM1CDK2 | |
| SCHEMBL8985408 | 0.77 | PTGS2 (0.52) | AURKAROCK2CHEK2PIM1CDK2 | |
| SCHEMBL8985293 | 0.76 | MC4R (0.37) | AURKAROCK2CHEK2PIM1CDK2 | |
| SCHEMBL8985255 | 0.73 | MAPK14 (0.45) | PTGS2PTGS1OPRD1 | |
| SCHEMBL8985338 | 0.73 | MAPK14 (0.46) | PTGS2PTGS1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |